LncRNAs are central for a number of biological activities. Housekeeping ncRNAs and regulatory ncRNAs are two classes of non-coding RNAs (ncRNAs) that have restricted or no capability to code for proteins based on their biological roles. Housekeeping ncRNAs: These ncRNA molecules are continuously made in high amounts throughout the cell. Their main job is to maintain … Read more
The particular amount of long RNA transcripts that aid as precursors for small RNA species is still undefined. Recent research using array-based approaches on human cell lines has shown that a prominent percentage of small RNAs arises from longer RNA precursors. However, only a small proportion of these long RNAs actually coincide with small RNAs … Read more
Although RNA that does not translate into protein is often referred to as non-coding RNA (ncRNA), this does not suggest that such RNAs are functionless or lacking of information. Though it has long been thought that proteins carry out the common of genetic information transfer, new research designates that most genomes of mammals and other … Read more
The controlling pathways and mechanisms of action of some endogenous miRNAs in animal models of neurodegenerative disorders are defined in the succeeding parts. This moreover generates a broad map to elucidate how these miRNAs are expressed in neurodegenerative disorders. miR-9 According to Sempere et al. (2004), miR-9 is highly expressed in the brains of equally … Read more
Parkinson’s disease (PD) is a complex and commonly spread neurodegenerative disorder that origins an extensive series of motor and non-motor indications. It is affected by the decline of dopamine neurons in the substantia nigra. There are many biomarkers for Parkinson’s disease (PD), like imaging biomarkers, inflammatory biomarkers, clinical biomarkers including sleep behavior disorder and fast … Read more
Autophagy is a cellular cytoplasmic degradation mechanism in which cell recycles broken or unnecessary proteins and organelles in the cell to get rid of these products. In order to save homeostasis and survival throughout times of metabolic stress, these intracellular essentials are recycled and provide an additional energy source. Autophagy allows longer survival in tumor … Read more
